منابع مشابه
CCR4 drives ATLL jail break
2482 INSIGHTS | The Journal of Experimental Medicine Malaria is caused by Plasmodium parasites and is commonly thought of as a disease resulting from the cyclic infection and destruction of red blood cells. However, a subset of infected individuals will develop “cerebral malaria”—a pathogenic neuroinflammation, presumably caused by parasitized red blood cells sequestering in the brain. Those af...
متن کاملMutant JAK3 FERMents ATLL.
Loss-of-function mutations in Janus kinase 3 (JAK3) are an underlying cause of severe combined immunodeficiency (SCID), whereas hyperactive JAK3 mutants have been identified in hematolocigal malignancies.1-3 In this issue of Blood, Elliot et al place JAK3 again under the magnifying lens and describe novel gain-of-function mutations in the FERM (Founding members: band 4.1, Ezrin, Radixin, and Mo...
متن کاملThe CC chemokine receptor 4 as a novel specific molecular target for immunotherapy in adult T-Cell leukemia/lymphoma.
Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T-cell neoplasm with dismal prognosis, and no optimal therapy has been developed. We tested the defucosylated chimeric anti-CC chemokine receptor 4 (CCR4) monoclonal antibody, KM2760, to develop a novel immunotherapy for this refractory tumor. In the presence of peripheral blood mononuclear cells (PBMCs) from healthy adult donors, KM2760 ind...
متن کاملThe Jail and Jail System of India
given in full, with their reasons for assigning the punishment for life only :? " We have ready made to our hands a weapon of tremendous power. The horror with which the people regard transportation is a feeling born with them, and the questions whether it bo a wise or foolish feeling, whether it be a just deduction from true premises, or the result of ignorance and superstition, are nothing to...
متن کاملJail Stomatitis
Sir ?I have read, with much interest, the paper entitled " Jail Stomatitis," by Dr. Nobin Chunder Dutt, in your issue of May last, and, as you have invited discussion, I venture to offer a few remarks on the subject, based upon an experience of several jails in the Punjab, during the past five years. Dr. Dutt describes a variety of conditions of the mouth under the head of stomatitis, and, for ...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2014
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.21113insight5